Poor oral health-related quality of life (OHRQoL) · children
Age 5 years was associated with higher odds of poor OHRQoL than age older than 5 years.
1 finding from 1 review
OR 3.68 [2.20, 5.17]
1 study
GRADE not reported
Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls
The pooled odds ratio was 1.04 (95% CI 0.29 to 3.75).
1 finding from 1 review
OR 1.04 [0.29, 3.75]
1 study
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
The pooled odds ratio was 2.90 (95% CI 0.92 to 9.12).
1 finding from 1 review
Intervention not reported
Dental caries in primary teeth · Children (primary dentition) worldwide
In the Americas, the pooled prevalence of primary-teeth caries in children was 45.8% (95% CI 34.2 to 58.0); certainty not graded.
1 finding from 1 review
Intervention not reported
Absence of recurrent caries success rate
1 finding from 1 review
Dental erosion · adults
The review found a higher prevalence of dental erosion in reflux patients than healthy individuals but did not formally demonstrate causation.
1 finding from 1 review
no estimate extracted
18 studies
GRADE not reported
Intervention not reported
Marginal integrity success rate
1 finding from 1 review
Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls
The pooled odds ratio was 1.42 (95% CI 0.54 to 3.76).
1 finding from 1 review
OR 1.42 [0.54, 3.76]
2 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
The pooled odds ratio was 1.83 (95% CI 0.47 to 7.06).
1 finding from 1 review
Diagnostic odds ratio (DOR) by subgroup: Primary dentition (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Fibre-optic transillumination (FOTI, including white light scattering and near infrared) vs Reference standard: histology or enhanced visual-tactile examination
Outcome not reported · Adults presenting asymptomatically or suspected of having root caries (in vivo); extracted teeth of adults (in vitro)
The review found no eligible studies for this question.
1 finding from 1 review
Dental erosion, alveolar bone destruction and oral/pharyngeal lesions · Rat models with surgically induced or chronic acid gastroesophageal reflux
In experimental rat models, induced gastroesophageal reflux caused dental erosion, alveolar bone destruction and oral lesions compared with controls, supporting biological plausibility; evidence is ungraded animal research.
1 finding from 1 review
Two rat-model studies found significantly higher rates of dental erosion, alveolar bone destruction and osteomyelitis (Higo) and shorter molar crown heights with dentin exposure, inflammatory infiltration and fibrosis…
2 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
The pooled odds ratio was 0.89 (95% CI 0.23 to 3.48).
1 finding from 1 review
Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls
The pooled odds ratio was 0.98 (95% CI 0.46 to 2.07).
1 finding from 1 review
OR 0.98 [0.46, 2.07]
1 study
GRADE not reported
Salivary buffering capacity · Patients with drooling (sialorrhea) due to neurological disease
Salivary buffering capacity did not decrease after BoNT; one of two quasi-experimental studies reported a significant increase (ungraded; no effect estimate reported).
1 finding from 1 review
Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomesBefore vs after BoNT injection (2018 study: significant buffering increase at 1 month; 2017 study no change) · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care
The quasi-experimental studies of Tiigimae-Saar found different results concerning the changes in buffering capacity. For the analysis carried out in 2017, no statistically significant change was observed. By contrast,…
2 studies
GRADE not reported
Diagnostic accuracy (sensitivity and specificity) for detection of early enamel caries (D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Fluorescence devices for the detection of dental caries 2020 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies)
Analysed as a separate index test (coupled forest plot and SROC plot, Figure 22 / Figure 23; Appendix 5); no summary DOR or sensitivity/specificity point reported numerically in the text. 4 datasets, 356 tooth sites.
4 studies
GRADE not reported
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
Orthodontic treatment need was associated with modestly higher odds of poor OHRQoL (OR 1.13, 95% CI 1.07-1.18; 3 studies; ungraded).
1 finding from 1 review
OR 1.13 [1.07, 1.18]
3 studies
GRADE not reported
Intervention not reported
Dental caries in primary teeth · Children (primary dentition) worldwide
The pooled worldwide prevalence of dental caries in primary teeth in children was 46.2% (95% CI 41.6 to 50.8), with very high heterogeneity (I2=99.2%); certainty not graded.
1 finding from 1 review
Oral mucosa inflammation (gingivitis, periodontitis, mucosal lesions) · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)
The association between reflux and oral mucosa inflammation (gingivitis/periodontitis) is inconsistent across five studies and remains ungraded.
1 finding from 1 review
Five studies examined gingival/periodontal and mucosal disorders with inconsistent results: some reported more frequent mucosal inflammatory findings in GERD patients (Yoshikawa, Watanabe, Vinesh 25.5% periodontitis,…
5 studies
GRADE not reported
Diagnostic odds ratio (DOR) by subgroup: Multiple sites per tooth (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review