Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,510 questions · 2,653 findings · 194 reviews · Gynaecology and Fertility

No studies found 531 · 20%GRADE not reported 76 · 2.9%Very low 826 · 31.1%Low 855 · 32.2%Moderate 341 · 12.9%High 24 · 0.9%

Laparoscopic myomectomy vs open myomectomy (all types)

Perioperative in‐hospital adverse events; laparoconversion · women with uterine fibroids

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; laparoconversion compared with open myomectomy (all types) (moderate certainty).

1 finding from 1 review

Laparoscopic myomectomy vs open myomectomy (all types)

Perioperative in‐hospital adverse events; injury to pelvic organs · women with uterine fibroids

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; injury to pelvic organs compared with open myomectomy (all types) (moderate certainty).

1 finding from 1 review

Uterine artery embolization (UAE) vs surgery

Adverse events: minor post‐procedural complications within one year · patients with symptomatic uterine fibroids

Uterine artery embolization (UAE) probably leads to higher adverse events: minor post‐procedural complications within one year compared with surgery (moderate certainty).

1 finding from 1 review

Uterine artery embolization (UAE) vs surgery

Adverse events: major post‐procedural complications within one year · patients with symptomatic uterine fibroids

Uterine artery embolization (UAE) showed no clear difference in adverse events: major post‐procedural complications within one year compared with surgery (moderate certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Loop ligation of myoma pseudocapsule plus vasopressin · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in loop ligation of myoma pseudocapsule plus vasopressin compared with placebo or no treatment (low certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Fibrin sealant patch (collagen sponge with thrombin and fibrinogen) · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in fibrin sealant patch (collagen sponge with thrombin and fibrinogen) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Misoprostol vs placebo to reduce blood loss during myomectomy

Blood loss (ml) Estimated blood loss during myomectomy · women with uterine fibroids

Misoprostol showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo to reduce blood loss during myomectomy (moderate certainty).

1 finding from 1 review

Vasopressin vs placebo to reduce blood loss during myomectomy

Blood loss (ml) Estimated blood loss during myomectomy · women with uterine fibroids

Vasopressin showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo to reduce blood loss during myomectomy (moderate certainty).

1 finding from 1 review

Bupivicaine plus epinephrine vs placebo to reduce blood loss during myomectomy

Blood loss (ml) Estimated blood loss during myomectomy · women with uterine fibroids

Bupivicaine plus epinephrine showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo to reduce blood loss during myomectomy (low certainty).

1 finding from 1 review