What do systematic reviews say?

IV + inhaled beta agonist vs inhaled beta‐agonist

IV + inhaled beta agonist showed no clear difference in pulse rate at 2 hours compared with inhaled beta‐agonist (moderate certainty).

• Addition of intravenous beta₂‐agonists to inhaled beta₂‐agonists for acute asthma 2012 · Cochrane Headline outcomes only
  MD 10
  1 study · 29 participants
  Moderate

IV + inhaled beta agonist vs inhaled beta‐agonist

IV + inhaled beta agonist probably leads to lower clinical Failure (children with a severe to moderate overall… compared with inhaled beta‐agonist (moderate certainty).

• Addition of intravenous beta₂‐agonists to inhaled beta₂‐agonists for acute asthma 2012 · Cochrane Headline outcomes only
  OR 0.09 [0.02, 0.38]
  1 study · 29 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 73 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 59 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 59 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 82 participants
  Low

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 89 participants
  Moderate

Combination fluticasone/salmeterol vs budesonide/formoterol

Combination fluticasone/salmeterol showed no clear difference in participants experiencing exacerbations requiring oral steroid… compared with budesonide/formoterol (moderate certainty).

• Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
  OR 0.89 [0.74, 1.07]
  4 studies · 4949 participants
  Moderate

Combination fluticasone/salmeterol vs budesonide/formoterol

Combination fluticasone/salmeterol showed no clear difference in participants experiencing exacerbations requiring admission to… compared with budesonide/formoterol (moderate certainty).

• Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
  OR 1.29 [0.68, 2.47]
  4 studies · 4879 participants
  Moderate

Combination fluticasone/salmeterol vs budesonide/formoterol

Combination fluticasone/salmeterol showed no clear difference in asthma‐related serious adverse event compared with budesonide/formoterol (moderate certainty).

• Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
  OR 1.47 [0.75, 2.86]
  3 studies · 4054 participants
  Moderate

Combination fluticasone/salmeterol vs budesonide/formoterol

• Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 4819 participants
  Low

Combination fluticasone/salmeterol vs budesonide/formoterol

Combination fluticasone/salmeterol showed no clear difference in withdrawals (adverse events) compared with budesonide/formoterol (moderate certainty).

• Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
  OR 0.94 [0.6, 1.46]
  5 studies · 5082 participants
  Moderate

Intervention not reported

• Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 367 participants
  Moderate

Intervention not reported

• Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 188 participants
  Moderate

Intervention not reported

• Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 94 participants
  Moderate

Intervention not reported

• Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 77 participants
  Low

Intervention not reported

• Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Low

Intervention not reported

• Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 41 participants
  Low

Intervention not reported

• Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 287 participants
  Low

Intervention not reported

• Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 212 participants
  Moderate