What do systematic reviews say?

Complex information, support and training interventions vs information only

Complex information, support and training interventions probably leads to higher dropouts for any reason compared with information provision only (moderate certainty).

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  RR 1.51 [1.04, 2.2]
  12 studies · 1266 participants
  Moderate

Complex information, support and training interventions vs information only

The review found no eligible studies for this question.

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Complex information, support and training interventions vs information only

It is very uncertain whether complex information, support and training interventions changes institutional care ‐ nursing home placement compared with information provision only (very low certainty).

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  RR 2.67 [0.12, 60.93]
  1 study · 32 participants
  Very low

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 638 participants
  Moderate

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 311 participants
  Moderate

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

Complex information, support and training interventions showed no clear difference in dropouts for any reason compared with usual treatment, waiting list or attention control informations (low certainty).

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  RR 1.15 [0.87, 1.53]
  8 studies · 661 participants
  Low

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

Complex information, support and training interventions showed no clear difference in use of health and social resources compared with usual treatment, waiting list or attention control informations (moderate certainty).

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  Rate ratio 1.05 [0.93, 1.19]
  1 study · 4776 participants
  Moderate

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

It is very uncertain whether complex information, support and training interventions changes institutional care ‐ nursing home placement compared with usual treatment, waiting list or attention control informations (very low certainty).

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  RR 0.59 [0.11, 3.11]
  1 study · 34 participants
  Very low

Complex information, support and training interventions vs information only

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 650 participants
  Low

Complex information, support and training interventions vs information only

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 1100 participants
  Moderate

Complex information, support and training interventions vs information only

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 257 participants
  Low

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 344 participants
  Low
• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 108 participants
  Moderate

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

Discontinuing cholinesterase inhibitor showed no clear difference in dropout due to lack of efficacy of trial medication or deterioration… compared with continued cholinesterase inhibitor (low certainty).

• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  OR 1.53 [0.84, 2.76]
  4 studies · 583 participants
  Low

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

Discontinuing cholinesterase inhibitor showed no clear difference in adverse events (any) compared with continued cholinesterase inhibitor (low certainty).

• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  OR 0.85 [0.57, 1.27]
  4 studies · 446 participants
  Low

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

Discontinuing cholinesterase inhibitor showed no clear difference in serious adverse events (SAEs) compared with continued cholinesterase inhibitor (low certainty).

• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  OR 0.8 [0.46, 1.39]
  4 studies · 390 participants
  Low

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

Discontinuing cholinesterase inhibitor showed no clear difference in deaths compared with continued cholinesterase inhibitor (low certainty).

• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  OR 0.75 [0.36, 1.55]
  5 studies · 598 participants
  Low

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 183 participants
  Low

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 136 participants
  Low
• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 108 participants
  Moderate

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 411 participants
  Very low

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

• Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 314 participants
  Very low