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Bupropion plus varenicline showed no clear difference in smoking cessation (at least six months of compared with varenicline alone (moderate certainty).
Bupropion plus varenicline showed no clear difference in serious adverse events compared with varenicline alone (low certainty).
Bupropion plus varenicline showed no clear difference in dropouts due to treatment compared with varenicline alone (low certainty).
Antibiotics showed no clear difference in pain ‐ pain at 24 hours compared with placebo (high certainty).
Immediate antibiotics showed no clear difference in pain ‐ Pain at 11 to 14 days compared with expectant observation (low certainty).
Immediate antibiotics leads to higher vomiting, diarrhoea or rash compared with expectant observation (high certainty).
Immediate antibiotics showed no clear difference in abnormal tympanometry at 4 weeks compared with expectant observation (moderate certainty).
Antibiotics leads to lower pain ‐ pain at 2 to 3 days compared with placebo (high certainty).
Antibiotics showed no clear difference in pain ‐ pain at 4 to 7 days compared with placebo (high certainty).
Antibiotics probably leads to lower pain ‐ pain at 10 to 12 days compared with placebo (moderate certainty).
Antibiotics leads to higher vomiting, diarrhoea or rash compared with placebo (high certainty).
Antibiotics leads to lower abnormal tympanometry ‐ 2 to 4 weeks compared with placebo (high certainty).
Antibiotics showed no clear difference in abnormal tympanometry ‐ 3 months compared with placebo (high certainty).
Immediate antibiotics may leads to lower pain ‐ Pain at 2 to 3 days compared with expectant observation (low certainty).
Immediate antibiotics showed no clear difference in pain ‐ Pain at 3 to 7 days compared with expectant observation (moderate certainty).
Antioxidant multivitamin and mineral supplement probably leads to lower progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo or no treatment (moderate certainty).
Lutein with or without zeaxanthin showed no clear difference in progression to geographic atrophy compared with placebo (low certainty).
Lutein with or without zeaxanthin showed no clear difference in progression to visual loss (loss of 3 or more lines on logMAR chart) compared with placebo (low certainty).
It is very uncertain whether lutein with or without zeaxanthin changes adverse effects compared with placebo (very low certainty).