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What do systematic reviews say?

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Evidence found and GRADE certainty

2,119 questions · 2,206 findings · 117 reviews · Common Mental Disorders

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No studies found 387 · 17.5%GRADE not reported 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Exercise vs control

Secondary outcome: acceptability of treatment · depression in adults
1 finding from 1 review
  • Exercise for depression 2013 · Cochrane Headline outcomes only
    no estimate extracted
    29 studies · 1363 participants
    Moderate

Exercise vs control

Quality of life · depression in adults
1 finding from 1 review
  • Exercise for depression 2013 · Cochrane Headline outcomes only
    no estimate extracted
    0 studies · 4 participants
    GRADE not reported

COMPARISON 1. ARIPIPRAZOLE vs placebo

≥ 50% decrease in total YMRS from baseline at three weeks Young Mania Rating Scale (as above) · patients with an acute manic or mixed episode

Aripiprazole probably leads to higher ≥ 50% decrease in total YMRS from baseline at three weeks Young… compared with placebo (moderate certainty).

1 finding from 1 review

COMPARISON 1. ARIPIPRAZOLE vs placebo

Numbers completing double‐blind treatment Number of participants · patients with an acute manic or mixed episode

Aripiprazole showed no clear difference in numbers completing double‐blind treatment Number of participants compared with placebo (moderate certainty).

1 finding from 1 review

COMPARISON 1. ARIPIPRAZOLE vs placebo

Requirement for anticholinergics number of participants requiring medication for extrapyramidal side effects · patients with an acute manic or mixed episode

Aripiprazole leads to higher requirement for anticholinergics number of participants requiring… compared with placebo (high certainty).

1 finding from 1 review