Findings

What do systematic reviews say?

2,119 questions · 2,206 findings · 117 reviews · Common Mental Disorders

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No studies found 387 · 17.5%GRADE not reported 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Fluoxetine vs moclobemide

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 540 participants
Moderate

Fluoxetine vs moclobemide

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with moclobemide (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.01 [0.7, 1.45]
7 studies · 721 participants
Moderate

Fluoxetine vs moclobemide

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with moclobemide (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.7 [0.32, 1.56]
6 studies · 679 participants
Moderate

Fluoxetine vs moclobemide

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with moclobemide (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.07 [0.64, 1.8]
7 studies · 721 participants
Moderate

Fluoxetine vs nefazodone

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Fluoxetine vs nefazodone

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 271 participants
Moderate

Fluoxetine vs nefazodone

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with nefazodone (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.54 [0.22, 1.31]
3 studies · 161 participants
Moderate

Fluoxetine vs nefazodone

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with nefazodone (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.71 [0.05, 10.71]
3 studies · 161 participants
Moderate

Fluoxetine vs ABT‐200

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with ABT‐200 (low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.24 [0.03, 2.2]
1 study · 144 participants
Low

Fluoxetine vs nefazodone

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with nefazodone (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.76 [0.32, 1.81]
4 studies · 286 participants
Moderate

Fluoxetine vs paroxetine

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine showed no clear difference in failure to respond (reduction ≥ 50% on HDRS) compared with paroxetine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.23 [0.93, 1.65]
9 studies · 1574 participants
Moderate

Fluoxetine vs paroxetine

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 2061 participants
Moderate

Fluoxetine vs paroxetine

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with paroxetine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.98 [0.81, 1.2]
10 studies · 1848 participants
Moderate

Fluoxetine vs paroxetine

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with paroxetine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.75 [0.41, 1.39]
4 studies · 1005 participants
Moderate

Fluoxetine vs paroxetine

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with paroxetine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.85 [0.62, 1.16]
9 studies · 1509 participants
Moderate

Fluoxetine vs phenelzine

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

It is very uncertain whether fluoxetine changes failure to respond (reduction ≥ 50% on HDRS) compared with phenelzine (very low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.42 [0.27, 7.34]
1 study · 40 participants
Very low

Fluoxetine vs phenelzine

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Fluoxetine vs phenelzine

Failure to complete ‐ total ‐ · patients with depression

It is very uncertain whether fluoxetine changes failure to complete ‐ total ‐ compared with phenelzine (very low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.18 [0.01, 4.01]
1 study · 40 participants
Very low

Fluoxetine vs phenelzine

Failure to complete ‐ inefficacy ‐ · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Exercise vs control

Symptoms of depression (long‐term) different scales · depression in adults

2 findings from 1 review

Exercise for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
35 studies · 1353 participants
Moderate
Exercise for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 377 participants
Low