Findings

What do systematic reviews say?

671 questions · 731 findings · 61 reviews · Drugs and Alcohol

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No studies found 57 · 7.8%GRADE not reported 39 · 5.3%Very low 186 · 25.4%Low 239 · 32.7%Moderate 171 · 23.4%High 39 · 5.3%

Baclofen vs placebo

AW delirium · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Baclofen vs chlordiazepoxide

AW delirium · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Baclofen vs chlordiazepoxide

AW symptoms (CIWA‐Ar score) · people with alcohol withdrawal

It is very uncertain whether baclofen changes AW symptoms (CIWA‐Ar score) compared with chlordiazepoxide (very low certainty).

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
MD 1 [0.7, 1.3]
1 study · 60 participants
Very low

Baclofen vs chlordiazepoxide

Global improvement · people with alcohol withdrawal

It is very uncertain whether baclofen changes global improvement compared with chlordiazepoxide (very low certainty).

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
MD 0.1
1 study · 60 participants
Very low

Baclofen vs chlordiazepoxide

Craving · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Baclofen vs chlordiazepoxide

AEs · people with alcohol withdrawal

It is very uncertain whether baclofen changes AEs compared with chlordiazepoxide (very low certainty).

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
RR 2.5 [0.88, 7.1]
1 study · 60 participants
Very low

Baclofen vs chlordiazepoxide

Severe AEs · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Baclofen vs chlordiazepoxide

Leaving the study early · people with alcohol withdrawal

It is very uncertain whether baclofen changes dropouts compared with chlordiazepoxide (very low certainty).

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
RD 0
1 study · 60 participants
Very low

Baclofen vs chlordiazepoxide

Dropouts due to adverse events · people with alcohol withdrawal

It is very uncertain whether baclofen changes dropouts due to AEs compared with chlordiazepoxide (very low certainty).

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
RD 0
1 study · 60 participants
Very low

Baclofen vs placebo

AW symptoms (CIWA‐Ar score) · people with alcohol withdrawal

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low

Baclofen vs placebo

Global improvement · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Baclofen vs placebo

Craving · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Baclofen vs placebo

AEs · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Baclofen vs placebo

Severe AEs · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Baclofen vs placebo

Leaving the study early · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Baclofen vs placebo

Dropouts due to adverse events · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen for alcohol withdrawal 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Δ9‐Tetrahydrocannabinol preparation vs placebo

Abstinence · cannabis dependence

Δ9‐Tetrahydrocannabinol preparation showed no clear difference in participants abstinent at end of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 0.98 [0.64, 1.52]
3 studies · 305 participants
Moderate

Mixed action antidepressant vs placebo

Participants with at least some Side Effects · cannabis dependence

Mixed action antidepressant showed no clear difference in participants experiencing adverse effects compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 0.93 [0.55, 1.55]
1 study · 76 participants
Low

Mixed action antidepressant vs placebo

Withdrawals due to adverse events · cannabis dependence

Mixed action antidepressant showed no clear difference in participants withdrawn due to adverse effects compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 1.44 [0.11, 18.9]
2 studies · 179 participants
Low

Mixed action antidepressant vs placebo

Completion of scheduled treatment · cannabis dependence

Mixed action antidepressant showed no clear difference in completion of scheduled treatment compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 0.93 [0.71, 1.21]
2 studies · 169 participants
Low