Findings

What do systematic reviews say?

3 questions · 4 findings · 3 reviews · Developmental, Psychosocial and Learning Problems

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No studies found 0 · 0%GRADE not reported 2 · 50%Very low 1 · 25%Low 1 · 25%Moderate 0 · 0%High 0 · 0%

D‐cycloserine vs placebo

Total adverse events · children aged 5 to 11 years with ASD

D‐cycloserine showed no clear difference in total adverse events compared with placebo (low certainty).

1 finding from 1 review

The effectiveness and adverse effects of D‐cycloserine compared with placebo on social and communication skills in… 2021 · Cochrane Headline outcomes only
RR 1.11 [0.94, 1.31]
1 study · 67 participants
Low

High‐dose methylphenidate vs placebo

Total number of adverse events · Children aged 6 to 18 years with ASD

2 findings from 1 review

Methylphenidate for children and adolescents with autism spectrum disorder 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
GRADE not reported
Methylphenidate for children and adolescents with autism spectrum disorder 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 79 participants
GRADE not reported

Intervention not reported

Serious adverse events Measured by: proportion of serious adverse events (total) Average study duration (range): not stated · children and adolescents aged 18 years and under diagnosed with ADHD

It is very uncertain whether the intervention changes serious adverse events Measured by: proportion of serious adverse… (very low certainty).

1 finding from 1 review

Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of… 2018 · Cochrane Headline outcomes only
RR 1.36 [1.17, 1.57]
2 studies · 72005 participants
Very low