Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

10 questions · 10 findings · 6 reviews · Childhood Cancer

No studies found 2 · 20%GRADE not reported 0 · 0%Very low 0 · 0%Low 6 · 60%Moderate 2 · 20%High 0 · 0%

Dinutuximab‐containing immunotherapy vs usual care

Overall survival (reported as mortality) · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

Dinutuximab‐containing immunotherapy probably leads to lower overall survival (reported as mortality) compared with standard therapy (moderate certainty).

1 finding from 1 review

Summary of findings: urate oxidase vs allopurinol

Mortality due to tumour lysis syndrome · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: urate oxidase may leads to lower mortality due to tumour lysis syndrome ( compared with allopurinol (low certainty).

1 finding from 1 review

Retinoic acid post‐consolidation therapy vs no further treatment

Overall survival (reported as mortality) · high‐risk neuroblastoma patients treated with autologous HSCT

Retinoic acid postconsolidation therapy showed no clear difference in overall survival (reported as mortality) compared with no further treatment (low certainty).

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Treatment‐related mortality ‐ not reported · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review

Dexrazoxane vs no cardioprotective intervention

Has died · children with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in overall mortality (Reported as number of participants who died) compared with no cardioprotective intervention (low certainty).

1 finding from 1 review

Sodium thiosulfate vs no otoprotective intervention

Overall survival with intravenous platinum (i.e. mortality/number of participants deceased) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in overall survival with intravenous platinum (i.e. mortality/number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Event‐free survival · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

Dinutuximab‐containing immunotherapy probably leads to lower event‐free survival (reported as relapse, progressive disease,… compared with standard therapy (moderate certainty).

1 finding from 1 review