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What do systematic reviews say?

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Evidence found and GRADE certainty

4 questions · 4 findings · 1 reviews · Methodology

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Risk‐based vs extensive on‐site monitoring

Combined outcome of proportion of participants with major or critical monitoring findings · clinical trials in all fields of health care

Risk‐based showed no clear difference in combined outcome of proportion of participants with major or… compared with extensive on‐site monitoring (moderate certainty).

1 finding from 1 review

Central and local monitoring only vs central and local monitoring with on‐site visits

Combined outcome of proportion of participants with major or critical monitoring findings · clinical trials in all fields of health care

Central and local monitoring only probably leads to higher combined outcome of proportion of participants with major or… compared with central and local monitoring with on‐site visits (moderate certainty).

1 finding from 1 review