What do systematic reviews say?

Central and local monitoring only vs central and local monitoring with on‐site visits

It is very uncertain whether central and local monitoring only changes impact of the monitoring strategy on compared with central and local monitoring with on‐site visits (very low certainty).

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  OR 0.8 [0.5, 1.1]
  1 study · 4371 participants
  Very low

Remote or targeted source data verification vs 100% source data verification

The review found no eligible studies for this question.

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Monitoring with vs without initiation visit

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 573 participants
  Very low

Risk‐based vs extensive on‐site monitoring

The review found no eligible studies for this question.

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Central monitoring with triggered vs untriggered on‐site visits

The review found no eligible studies for this question.

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Central and local monitoring only vs central and local monitoring with on‐site visits

The review found no eligible studies for this question.

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Remote or targeted source data verification vs 100% source data verification

The review found no eligible studies for this question.

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Central monitoring with triggered vs untriggered on‐site visits

The review found no eligible studies for this question.

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Risk‐based vs extensive on‐site monitoring

The review found no eligible studies for this question.

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Monitoring with vs without initiation visit

• Monitoring strategies for clinical intervention studies 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 573 participants
  Very low