Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Moderate‐potency vs mild‐potency topical corticosteroid

Systemic adverse events: abnormal cortisol; end of treatment (1‐6 weeks) · children and adults with mild to severe eczema

It is very uncertain whether moderate‐potency changes systemic adverse events: abnormal cortisol; end of treatment (6‐28… compared with mild‐potency topical corticosteroid (very low certainty).

1 finding from 1 review

Valproate vs OLANZAPINE

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate leads to lower adverse events ‐ Sedation At 3‐12 weeks (secondary tolerability… compared with olanzapine (high certainty).

1 finding from 1 review

Tonsillectomy vs no intervention

Proportion of participants with adverse events and severe adverse events · people with chronic plaque psoriasis

It is very uncertain whether tonsillectomy changes proportion of participants with adverse events and severe adverse… compared with no intervention (very low certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events: aspiration (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events: aspiration (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

It is very uncertain whether enteral changes adverse events: aspiration (as reported by study authors at end of… compared with parenteral nutrition (very low certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Adverse effects: diarrhoea 48 to 72 hours · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in adverse events during first 48‐72 hours post supplementation ‐… compared with control (low certainty).

1 finding from 1 review