What do systematic reviews say?

CP gel in tray vs HP gel in tray

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  No difference between HP and CP in tray groups in tooth sensitivity and oral irritation
  3 studies
  GRADE not reported

HP strips vs HP strips

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Very thin gel had less tooth sensitivity than thicker gel despite higher HP; not significant
  2 studies
  GRADE not reported

SPC paint-on gel vs HP paint-on gel

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Tooth sensitivity in one subject from both groups; one subject in 19% SPC reported oral sensitivity; all mild (Gerlach 2003)
  1 study
  GRADE not reported

STPP chewing gum vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

Resin-based fissure sealant (2nd/3rd/4th generation) vs No sealant (control/no treatment)

• Pit and fissure sealants for preventing dental decay in permanent teeth 2017 · Cochrane All outcomes
  Two trials measured adverse effects. None were reported.
  2 studies
  GRADE not reported

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No evidence of a difference in reported adverse events across the three trials (nausea, fever, constipation, diarrhoea, headache, fatigue and others)
  3 studies
  GRADE not reported

Amifostine (intravenous) vs Amifostine (subcutaneous)

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  Increased hypotension with intravenous delivery (20% vs 8%; P = 0.007); skin rash (10% vs 22%; P = 0.012) and local pain at injection site (0% vs 8%; P = 0.001) worse with subcutaneous; inconclusive for…
  1 study
  GRADE not reported

Glass ionomer-based sealant vs No sealant (control/no treatment)

The review found no eligible studies for this question.

• Pit and fissure sealants for preventing dental decay in permanent teeth 2017 · Cochrane All outcomes
  Adverse effects not measured.
  Studies not reported
  No studies found

Beta‐carotene vs placebo

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  High

Vitamin C vs placebo

The review found no eligible studies for this question.

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multivitamin vs placebo

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Intervention not reported

The review found no eligible studies for this question.

• Interventions to change the behaviour of health professionals and the organisation of care to promote weight reduction… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Interventions to change the behaviour of health professionals and the organisation of care to promote weight reduction… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Interventions to change the behaviour of health professionals and the organisation of care to promote weight reduction… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Interventions to change the behaviour of health professionals and the organisation of care to promote weight reduction… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Interventions to change the behaviour of health professionals and the organisation of care to promote weight reduction… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Interventions to change the behaviour of health professionals and the organisation of care to promote weight reduction… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Interventions to change the behaviour of health professionals and the organisation of care to promote weight reduction… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Computer‐generated reminders delivered on paper to healthcare professionals: effects on professional practice and… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Computer‐generated reminders delivered on paper to healthcare professionals: effects on professional practice and… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found