Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

347 questions · 355 findings · 51 reviews

No studies found 135 · 38%GRADE not reported 45 · 12.7%Very low 90 · 25.4%Low 63 · 17.7%Moderate 15 · 4.2%High 7 · 2%

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

Serious adverse events · Children and adolescents with femoral shaft fractures

Surgical interventions may leads to higher serious adverse events compared with conservative interventions (low certainty).

1 finding from 1 review

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

Time to return to usual activities⁶(time to return to school) · Children and adolescents with femoral shaft fractures
1 finding from 1 review

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

Child satisfaction Assessed by an ordinal rating scale (11 points): very unhappy to very happy · Children and adolescents with femoral shaft fractures
1 finding from 1 review

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

Parent satisfaction Rated as excellent or good · Children and adolescents with femoral shaft fractures

Surgical interventions may leads to higher parent satisfaction Rated as excellent or good compared with conservative interventions (low certainty).

1 finding from 1 review

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

Resource use and other costs · Children and adolescents with femoral shaft fractures

The review found no eligible studies for this question.

1 finding from 1 review

Non-surgical interventions vs Surgical interventions

Outcome not reported · People with at least one dental implant affected by peri-implantitis

The review found no eligible studies for this question.

1 finding from 1 review

Presurgical medical therapy vs postsurgical medical therapy

Pain recurrence (dichotomous) Pain recurrence ≤ 12 months · women having endometriosis surgery

Presurgical medical therapy showed no clear difference in pain recurrence (dichotomous) Pain recurrence ≤ 12 months compared with postsurgical medical therapy (low certainty).

1 finding from 1 review

Presurgical medical therapy vs Placebo or no active treatment

Pain recurrence (dichotomous) Pain recurrence ≤ 12 months · women having endometriosis surgery

It is very uncertain whether presurgical medical therapy changes pain recurrence (dichotomous) Pain recurrence ≤ 12 months compared with placebo or no medical therapy (very low certainty).

1 finding from 1 review

Presurgical medical therapy vs Placebo or no active treatment

Disease recurrence ≤ 12 months (EEC stage) · women having endometriosis surgery

It is very uncertain whether presurgical medical therapy changes disease recurrence ≤ 12 months (EEC stage) compared with placebo or no medical therapy (very low certainty).

1 finding from 1 review