Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Movement Disorders

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 3 · 42.9%High 0 · 0%

Change in IRLS severity scale score · patients with restless legs syndrome

1 finding from 1 review

Iron for the treatment of restless legs syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 345 participants
Moderate

Change in any measure of restlessness · patients with restless legs syndrome

1 finding from 1 review

Iron for the treatment of restless legs syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 370 participants
Moderate

Quality of life (dichotomous measure) · patients with restless legs syndrome

It is very uncertain whether iron changes quality of life (dichotomous measure) compared with placebo (very low certainty).

1 finding from 1 review

Iron for the treatment of restless legs syndrome 2019 · Cochrane Headline outcomes only
RR 2.01 [0.54, 7.45]
2 studies · 39 participants
Very low

Change in quality of life (continuous measure) · patients with restless legs syndrome

1 finding from 1 review

Iron for the treatment of restless legs syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 128 participants
Very low

Withdrew to use other RLS medication or because of inadequate RLS symptom control · patients with restless legs syndrome

Iron showed no clear difference in withdrew to use other RLS medication or because of inadequate RLS… compared with placebo (low certainty).

1 finding from 1 review

Iron for the treatment of restless legs syndrome 2019 · Cochrane Headline outcomes only
RR 0.77 [0.41, 1.47]
9 studies · 391 participants
Low

Adverse events · patients with restless legs syndrome

Iron showed no clear difference in adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Iron for the treatment of restless legs syndrome 2019 · Cochrane Headline outcomes only
RR 1.48 [0.97, 2.25]
6 studies · 298 participants
Moderate

Adverse effects (drop‐outs due to adverse effects4) · patients with restless legs syndrome

Iron showed no clear difference in drop out due to adverse event compared with placebo (low certainty).

1 finding from 1 review

Iron for the treatment of restless legs syndrome 2019 · Cochrane Headline outcomes only
RR 1.91 [0.5, 7.26]
9 studies · 398 participants
Low