Modafinil vs placebo: Mental state: clinically important change in general mental state ‐ worsening psychosis
Modafinil showed no clear difference in mental state: clinically important change in general mental state ‐… compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Modafinil vs placebo Mental state: clinically important change in general mental state ‐ worsening psychosis · schizophrenia or related disorders Modafinil showed no clear difference in mental state: clinically important change in general mental state ‐… compared with placebo (low certainty). Modafinil for people with schizophrenia or related disorders (2019) · Cochrane Headline outcomes only | RR 0.91 [0.28, 2.98] | 6 studies · 209 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Modafinil for people with schizophrenia or related disorders 2019 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.