Infliximab vs rituximab: Withdrawals due to adverse events
- Population
- adults (age 18 years and older) with refractory GPA ANCA‐associated vasculitis
- Intervention
- Infliximab
- Comparison
- rituximab
- Outcome
- Withdrawals due to adverse events
It is very uncertain whether infliximab changes any withdrawals due to AEs compared with rituximab (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Infliximab vs rituximab Any withdrawals due to AEs · adults (age 18 years and older) with refractory GPA ANCA‐associated vasculitis It is very uncertain whether infliximab changes any withdrawals due to AEs compared with rituximab (very low certainty). Anti‐cytokine targeted therapies for ANCA‐associated vasculitis (2020) · Cochrane Headline outcomes only | RR 2.7 [0.13, 58.24] | Not reported | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Anti‐cytokine targeted therapies for ANCA‐associated vasculitis 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.