Bae: AZT/3TC/NVP vs d4T/3TC/NVP: Maternal Grade 3/4 Severe Adverse Events
- Population
- HIV‐Infected Pregnant Women With CD4<350
- Intervention
- Bae: AZT/3TC/NVP
- Comparison
- d4T/3TC/NVP
- Outcome
- Maternal Grade 3/4 Severe Adverse Events
It is very uncertain whether jamisse (What to Start): AZT/3TC/NVP changes maternal Grade 3/4 Severe Adverse Events compared with d4T/3TC/NVP (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Jamisse (What to Start): AZT/3TC/NVP vs d4T/3TC/NVP Maternal Grade 3/4 Severe Adverse Events · HIV‐Infected Pregnant Women With CD4<350 It is very uncertain whether jamisse (What to Start): AZT/3TC/NVP changes maternal Grade 3/4 Severe Adverse Events compared with d4T/3TC/NVP (very low certainty). Antiretroviral therapy (ART) for treating HIV infection in ART‐eligible pregnant women (2010) · Cochrane Headline outcomes only | RR 1.58 [0.6, 4.12] | 1 study · 146 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiretroviral therapy (ART) for treating HIV infection in ART‐eligible pregnant women 2010 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Bae: AZT/3TC/NVP vs AZT/3TC/NVP · HIV‐1 Infected Pregnant Women Who Have CD4>200 Compared with Those Who Have CD4<200… · 1 review
- Bae: AZT/3TC/NVP vs AZT/3TC/NVP · HIV‐infected pregnant women · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.