Question · asked by 1 review

Erlotinib vs control: Overall survival

Erlotinib showed no clear difference in overall survival compared with control (high certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Erlotinib vs control
Overall survival · EGFR M+ patients with NSCLC
Erlotinib showed no clear difference in overall survival compared with control (high certainty).
First‐line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non‐squamous… (2021) · Cochrane Headline outcomes only
HR 0.95 [0.75, 1.22]3 studies · 429 participantsHigh

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
First‐line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non‐squamous non‐small cell lung cancer
2021 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.