Question · asked by 1 review
PRO 140 vs placebo: Antiviral response: 10 mg/kg
- Population
- patients being treated for HIV infection
- Intervention
- PRO 140
- Comparison
- placebo
- Outcome
- Antiviral response: 10 mg/kg
It is very uncertain whether PRO 140 changes antiviral response: 10 mg/kg compared with placebo (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
PRO 140 vs placebo Antiviral response: 10 mg/kg · patients being treated for HIV infection It is very uncertain whether PRO 140 changes antiviral response: 10 mg/kg compared with placebo (very low certainty). Humanized PA14 (a monoclonal CCR5 antibody) for treatment of people with HIV infection (2014) · Cochrane Headline outcomes only | OR 145.67 [5.3, 4004.91] | 1 study · 21 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Humanized PA14 (a monoclonal CCR5 antibody) for treatment of people with HIV infection 2014 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.