Rituximab vs other disease‐modifying treatments: Fingolimod (Direct evidence; 2 RCTs; 2355 participants)
Rituximab as 'switching' probably leads to lower fingolimod compared with other disease‐modifying treatments (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Rituximab as 'switching' vs other disease‐modifying treatments Fingolimod · relapsing multiple sclerosis Rituximab as 'switching' probably leads to lower fingolimod compared with other disease‐modifying treatments (moderate certainty). Rituximab for people with multiple sclerosis (2021) · Cochrane Headline outcomes only | HR 0.08 [0.02, 0.32] | 256 participants | Moderate |
Rituximab as 'first choice' vs other disease‐modifying treatments Fingolimod · relapsing multiple sclerosis It is very uncertain whether rituximab as 'first choice' changes fingolimod compared with other disease‐modifying treatments (very low certainty). Rituximab for people with multiple sclerosis (2021) · Cochrane Headline outcomes only | HR 0.26 [0.04, 1.69] | 137 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Rituximab for people with multiple sclerosis 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.