Same question across reviews · CL0296
intervention :: Xylitol/polyols -> Adverse effects/fluorosis
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
1
Questions
5
current versions
GRADE rated
0
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Xylitol lozenges (4.7 g/day) vs No treatment Adverse effects · Children (permanent teeth; baseline 8 to 10 years) · 24 months (48-month follow-up) Xylitol‐containing products for preventing dental caries in children and adults (2015) · Cochrane | There were no usable data presented for adverse effects. Lenkkeri 2012. | 1 study | Ungraded |
Xylitol syrup (high dose, 8 g/day) vs Control (low-dose xylitol, 2.67 g/day) syrup Adverse effects (loose stools, diarrhoea) · Infants (primary teeth; baseline about 9 to 15 months) · 12 months Xylitol‐containing products for preventing dental caries in children and adults (2015) · Cochrane | Adverse effects were not reported in a usable format, but the reported rates of loose stools and diarrhoea were very similar between groups. There were no serious adverse effects during the study. Milgrom 2009. | 1 study · 94 participants | Ungraded |
Xylitol candy (7.5 g/day) vs Control (sorbitol) candy Adverse effects · Children (mixed dentition; baseline about 8 years) · 36 months Xylitol‐containing products for preventing dental caries in children and adults (2015) · Cochrane | The authors reported that there were no adverse effects for either group. Honkala 2014. | 1 study · 252 participants | Ungraded |
Xylitol lozenges (5 g/day) vs Control lozenges (sucralose-sweetened placebo, no xylitol) Adverse effects (sores in the mouth, cramps, bloating, constipation, flatulence, loose stool or diarrhoea) · Adults · 33 months Xylitol‐containing products for preventing dental caries in children and adults (2015) · Cochrane | Patterns of adverse effects (sores in the mouth, cramps, bloating, constipation, flatulence, and loose stool or diarrhoea) were similar for both groups. Bader 2013. | 1 study · 669 participants | Ungraded |
Xylitol wipes (4.2 g/day) vs Control wipes (no xylitol) Adverse effects · Infants (primary teeth) · 12 months Xylitol‐containing products for preventing dental caries in children and adults (2015) · Cochrane | The authors reported that there were no adverse effects for either group. Zhan 2012. | 1 study · 44 participants | Ungraded |