Same question across reviews · CL0182
intervention :: Herbal/natural product -> Microbiological/plaque
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
1
Questions
7
current versions
GRADE rated
0
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Grape seed extract or grape seed flavonoid fractions vs No extract or vehicle control; other antimicrobial agents Biofilm morphology · Streptococcus mutans cultures and biofilms Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | no estimate extracted | 2 studies | Ungraded |
Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Biofilm formation (reduction) · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | Cranberry extract/PAC reduced S. mutans biofilm formation: 51% at 500 ug/mL (Philip 2019), 95.2% at 50 mg/mL (Sumathi), 50-70% of preformed biofilm at 16.67-20.83 mg/dL (Singhal), 32%/29%/14% at 500/250/125 ug/mL… | 10 studies | Ungraded |
Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | Cranberry treatment disrupted biofilm integrity with agglutination/cell degradation at higher concentrations (Singhal), reduced polymicrobial biomass 38% at 96 h (Philip 2019), produced defective accumulation and… | 4 studies | Ungraded |
Grape seed extract (GSE) and its proanthocyanidin fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | GSE decreased microcolony number and biofilm thickness at 2000 ug/mL (Furiga) and significantly altered bacterial cell structure with 50 ug/2 mL GSE candy (Nowaczyk). | 2 studies | Ungraded |
Grape seed extract (GSE) and its proanthocyanidin fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Biofilm formation (reduction) · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | GSE reduced biofilm formation: 89% (polymeric PAC) vs 79% (dealcoholized wine) (Daglia), inhibition at 4 mg/mL (Zhao), decreased microcolonies with 2000 ug/mL GSE + fluorinol (Furiga), reduction within 30 min… | 5 studies | Ungraded |
Cranberry extract or cranberry flavonoid fractions vs No extract or vehicle control; other antimicrobial agents Biofilm formation · Streptococcus mutans cultures and biofilms Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | no estimate extracted | 10 studies | Ungraded |
Cranberry extract or cranberry flavonoid fractions vs No extract or vehicle control; other antimicrobial agents Biofilm morphology or biomass · Streptococcus mutans cultures and biofilms Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | no estimate extracted | 4 studies | Ungraded |