Same question across reviews · CL0160
intervention :: Fluoride toothpaste/dentifrice -> White-spot/initial lesions
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
2
Questions
2
current versions
GRADE rated
1
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Control: fluoride toothpaste alone, placebo mouthrinse + toothpaste, or non-fluoride (chlorhexidine) mouthrinse + toothpaste Incidence of initial enamel caries / white spot lesions adjacent to bracket base (subject level, dichotomized) · Children, adolescents and adults undergoing fixed (multi-bracket) orthodontic treatment · End of intervention (6-26 months) to within 6 weeks after debonding Fluoride mouthrinses for prevention of initial caries in orthodontic patients - a systematic review and… (2025) | RD -0.07 [-0.14, -0.01] | 5 studies · 491 participants | Ungraded |
1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily vs 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily White spot lesion index (mean change from baseline) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; follow-up 1.5 years Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | MD -0.05 [-0.10, 0] | 1 study · 97 participants | Very low |