Same question across reviews · CL0145
intervention :: Fluoride supplements -> Adverse effects/fluorosis
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
2
Questions
5
current versions
GRADE rated
3
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Placebo or no treatment Adverse effects (apart from fluorosis) · Pregnant women (for preventing dental caries in the primary teeth of their children) Fluoride supplementation (with tablets, drops, lozenges or chewing gum) in pregnant women for preventing… (2017) · Cochrane | no estimate extracted | 1 study | Ungraded |
Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Placebo or no treatment Fluorosis (maxillary teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children) · 5 years Fluoride supplementation (with tablets, drops, lozenges or chewing gum) in pregnant women for preventing… (2017) · Cochrane | RR 1.79 [0.95, 3.40] | 1 study · 798 participants | Very low |
Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Placebo or no treatment Fluorosis (mandibular teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children) · 5 years Fluoride supplementation (with tablets, drops, lozenges or chewing gum) in pregnant women for preventing… (2017) · Cochrane | RR 0.89 [0.35, 2.29] | 1 study · 798 participants | Very low |
Fluoride supplements (tablets, drops, lozenges or chewing gums) vs Topical fluoride (fluoride rinse, varnish or toothpaste) Fluorosis (adverse effect; % of children with fluorotic teeth) · Children and adolescents (aged 16 years or less at baseline) Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children (2011) · Cochrane | Summary of findings 2 lists fluorosis (% of children with fluorotic teeth) as 'See comment / Not estimable / Not estimated'; no included study reported fluorosis for the fluoride supplements versus topical fluoride… | NR | No studies |
Fluoride supplements (tablets, drops, lozenges or chewing gums) vs No fluoride supplement (placebo or no treatment) Fluorosis (adverse effect; % of children with fluorotic teeth, questionable to severe) · Children and adolescents (aged 16 years or less at baseline) · 55 months Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children (2011) · Cochrane | % of children with fluorotic teeth (questionable to severe), follow-up 55 months. Assumed risk 32/212 = 15%; corresponding risk 40/202 = 20% (APF once a day) and 43/197 = 22% (APF twice a day). Relative effect: Not… | 1 study · 611 participants | Very low |