Same question across reviews · CL0125
intervention :: Fluoride gel/foam -> Adverse effects/fluorosis
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
3
Questions
4
current versions
GRADE rated
3
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fluoride gel (450 ppm) vs High-content fluoride toothpaste (1350 ppm) Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the… · 14 to 36 months Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy (2019) · Cochrane | Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events | 1 study · 220 participants | Very low |
12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel vs 0 ppm F placebo gel Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; mean follow-up 16.6 months Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | Additional SoF Table 1. Adverse effects: with placebo gel 0.60%; with fluoride gel 0.00% (0 to 0); difference 0.60% fewer (0.60 fewer to 0.60 fewer); relative effect not estimable; 312 participants (1 RCT); certainty… | 1 study · 312 participants | Very low |
Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs Placebo or no treatment Tooth staining · Children and adolescents aged 16 years or younger Fluoride gels for preventing dental caries in children and adolescents (2015) · Cochrane | None of the studies reported on staining of tooth surfaces (not even Gisselsson 1999, the only trial testing stannous fluoride). | 0 studies | No studies |
Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs Placebo or no treatment Signs of acute toxicity during gel application (nausea, gagging, vomiting) · Children and adolescents aged 16 years or younger · During gel application Fluoride gels for preventing dental caries in children and adolescents (2015) · Cochrane | RD 0.01 [-0.01, 0.02] | 2 studies · 490 participants | Very low |