Same question across reviews · CL0107
intervention :: Diet/sugar -> Microbiological/plaque
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
3
Questions
4
current versions
GRADE rated
0
Review overlap (CCA)
0.014
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Stevia (high-intensity/non-nutritive sweetener) in a daily snack vs Baseline (within-group change); white sugar snack is a parallel arm with no between-group effect size reported Change in Mutans streptococci (MS) and Lactobacilli in saliva · Schoolchildren (6-9 years), high caries risk · 42 days, Single study (Cocco 2019); not pooled Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. (2024) | Cocco 2019 (the only high-intensity sweetener trial): the stevia snack showed a significant decrease in MS (P < .01) and in lactobacilli (P = .03) versus baseline, whereas the white-sugar snack showed no significant… | 1 study · 271 participants | Ungraded |
Package of oral health education/promotion including oral hygiene advice for pregnant women, mothers, infants and young children, plus dietary and feeding practice advice for infants and young children vs Standard care Child microbiological presence (mutans streptococci colonisation) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | Yu 2021: MS colonisation level (CFU x10^4) lower with intervention at 2 yrs (MD -2.80) and 3 yrs (MD -15, 95% CI -27.75 to -2.25) but not 1 yr (MD -0.20, 95% CI -0.50 to 0.10); MS-to-total-bacteria ratio lower at 1 yr… | 1 study | Ungraded |
Gum chewing (sugar-free) vs No gum chewing (control) Salivary flow rate, stimulated and/or unstimulated (narrative synthesis) · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth · Various (single session to 12 months) The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised… (2023) | Narrative vote-count: of 19 studies measuring stimulated and/or unstimulated saliva flow rate, 9 found a positive effect of gum chewing [17,18,22,24,27,35,36,38,39] and 10 detected no effect… | 19 studies | Ungraded |
Gum chewing (sugar-free) vs No gum chewing (control) Unstimulated whole salivary flow rate · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth · Gum chewed daily for >=2 weeks (2 to 12 weeks; multiple time points for Kim and Ozen) The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised… (2023) | SMD 0.44 [0.22, 0.66] | 6 studies · 291 participants | Ungraded |