Same question across reviews · CL0011
aetiology :: Exposure: genetic -> Periodontal/gingival
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
1
Questions
2
current versions
GRADE rated
0
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Genome-wide common variants (additive dosage; present-study GWAS) vs Genome-wide significance threshold (P<5E-8) Periodontal disease - genome-wide-significant loci (present study) · Japanese adults (present-study cohort: 7,059 periodontal disease cases / 38,466 controls) · Lifelong (germline genotype), Present-study GWAS (Japanese) Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) | In the present Japanese GWAS, no loci reached genome-wide significance for periodontal disease; several loci reached the suggestive level (P<1E-5). Top-associated variant rs12624579 (SYNDIG1 intron). | 1 study · 45525 participants | Ungraded |
Genome-wide common variants (additive dosage; GWAS meta-analysis) vs Genome-wide significance threshold (P<5E-8) Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB + BBJ Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) | Meta-analysis of periodontal disease identified only previously known loci; no novel loci. The chromosome-19 SIGLEC5 locus associated with periodontitis in Europeans was not replicated in Japanese populations (present… | 4 studies · 764572 participants | Ungraded |