Same question across reviews · CL0009
aetiology :: Exposure: genetic -> Caries increment (DMFS/DMFT)
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
1
Questions
2
current versions
GRADE rated
0
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
rs10974056 effect allele A (intron variant in GLIS3, chr9:3,889,264) vs Non-effect allele C Dental caries (meta of mixed phenotypes: present-study self-report + GLIDE clinical DMFS + UKB self-report/dentures) · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) | Z-score (meta) -5.494 | 3 studies · 533348 participants | Ungraded |
rs4801882 effect allele G (intron variant in SIGLEC5, chr19:52,127,053) vs Non-effect allele A Dental caries (meta of mixed phenotypes: present-study self-report + GLIDE clinical DMFS + UKB self-report/dentures) · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) | Z-score (meta) -5.639 | 3 studies · 533348 participants | Ungraded |